Our Research Projects and Funding



CLAP Study
Now recruiting participants diagnosed with Bipolar Disorder.
Prinicipal Investigator: Anna Manelis, PhD
Co-Investigators: Mary Phillips, MD, Holly Swartz, MD
PUBLIC HEALTH RELEVANCE: The ability to prepare for emotional and cognitive tasks is critical to our daily life. The fact that individuals with unipolar depression and bipolar disorder are impaired on
Participation in the CLAP Study may
Participants must be:
- Between the ages of 18 and 45
- Native English speaker
- Have a history of depression/mania OR have NO history of any psychiatric disorders
- Not currently in a manic state
For more information:
Email: clap@upmc.edu (preferred)
Call: 412-799-6105 or 412-799-6106
SAND Behavioral Study
Now recruiting participants.
Principal Investigator: Anna Manelis, PhD
Co-Investigators: Mary Phillips, MD, Holly Swartz, MD
PUBLIC HEALTH RELEVANCE: The ability to prepare for emotional and cognitive tasks is critical to our daily life. Individuals with depression may experience impairment on tasks related to cognition and cognitive control. Macular degeneration also influences This project aims to examine how age, symptoms of depression, and age-related macular degeneration (AMD) affect people’s ability to perform tasks requiring cognitive control.
Participation in the SAND Study may involve: One visit which will take 2-4.5 hours. Participation in the study will involve completing surveys and questionnaires as well as computer-based tasks.
Participants must be:
- Between the ages of 18 and 85
- Have a history of depression OR have NO history of any psychiatric disorder
- Have a diagnosis of Macular degeneration OR have NO diagnosis of macular degeneration
If eligible, participants will be compensated.
For more information:
Email: sand@upmc.edu (preferred)
Call: 412-799-6105 OR 412-799-6106
SAND fMRI Study
Now recruiting participants.
Principal Investigator: Anna Manelis, PhD
Co-Investigators: Mary Phillips, MD, Holly Swartz, MD
PUBLIC HEALTH RELEVANCE: The ability to prepare for emotional and cognitive tasks is critical to our daily life. Individuals with depression may experience impairment on tasks related to cognition and cognitive control. Macular degeneration also influences This project aims to examine how age, symptoms of depression, and age-related macular degeneration (AMD) affect people’s ability to perform tasks requiring cognitive control.
Participation in the SAND Study may involve: One visit which will take approximately 2 hours. Participation in the study will involve completing surveys and questionnaires as well as a 30-minute functional magnetic resonance imaging (fMRI) scan. During the scan, we would ask you to lie still and complete a computerized task.
Participants must be:
- Between the ages of 65 and 80
- Have a history of depression OR have NO history of any psychiatric disorder
- Have a diagnosis of Macular degeneration OR have NO diagnosis of macular degeneration
If eligible, participants will be compensated.
For more information:
Email: sand@upmc.edu (preferred)
Call: 412-799-6105 OR 412-799-6106
BREATHE Study
Participants interested in the CLAP Study may also be interested in the BREATHE Study.
Follow the links below for more information.
Lab Website: https://hafemanresearchgroup.weebly.com
Lab Facebook: https://facebook.com/MoodDisorderEarlyInterventionResearch
Project Funding
Ongoing Research Support
R01 MH114870
Manelis, Anna (PI)
04/01/2018 – 01/31/2023
The contribution of aberrant anticipatory processing to spectrum depression and mania, and cognitive and emotional dysfunction in major depressive and bipolar disorders
Role: Principal Investigator
Past Research Support
K01 MH104348
Manelis, Anna (PI)
03/01/2015-01/31/2020
Task preparation abnormality in individuals with unipolar and bipolar depression
Role: Principal Investigator
R03 MH115894
Manelis, Anna (PI)
04/01/2018 – 03/31/2021
Aberrant brain functioning during working memory tasks in mood disorders across diagnoses and age groups: Secondary data analysis
Role: Principal Investigator